The calcined product obtained by the ordinary zinc-barium white preparation method is beaten into a slurry, which is then surface-treated with sodium silicate, aluminum sulfate or sodium aluminate and surfactant, and then filtered, washed, dried and pulverized. Can.

Solids were stable and did not show visible signs or changes in their spectra after being kept at room temperature for over 60 days. The absorbance at the maximum absorbance wavelength remained unmodified.

In 2017, French researchers from the Institut National de la Recherche Agronomique (INRAE) were among the first to examine the effects of E171 nanoparticles on the body. They fed rats a dose of 10mg of E171 per kilogram of body weight per day, which was similar to human exposure in food. The research, which was published in Scientific Reports, showed that E171 was able to traverse the intestinal barrier, pass into the bloodstream, and reach other areas of the body in rats. Researchers also found a link between immune system disorders and the absorption of titanium dioxide nanoparticles. 

Because of their small size, nanoparticles may have unique physical and chemical properties. These properties may cause them to interact with living systems differently than larger materials with the same chemical composition (also known as bulk materials).